Article
Novel mutations target distinct subgroups of medulloblastoma.
Nature - 2 Aug 2012
Robinson Giles, Parker Matthew, Kranenburg Tanya A, Lu Charles, Chen Xiang, Ding Li, Phoenix Timothy N, Hedlund Erin, Wei Lei, Zhu Xiaoyan, Chalhoub Nader, Baker Suzanne J, Huether Robert, Kriwacki Richard, Curley Natasha, Thiruvenkatam Radhika, Wang Jianmin, Wu Gang, Rusch Michael, Hong Xin, Becksfort Jared, Gupta Pankaj, Ma Jing, Easton John, Vadodaria Bhavin, Onar-Thomas Arzu, Lin Tong, Li Shaoyi, Pounds Stanley, Paugh Steven, Zhao David, Kawauchi Daisuke, Roussel Martine F, Finkelstein David, Ellison David W, Lau Ching C, Bouffet Eric, Hassall Tim, Gururangan Sridharan, Cohn Richard, Fulton Robert S, Fulton Lucinda L, Dooling David J, Ochoa Kerri, Gajjar Amar, Mardis Elaine R, Wilson Richard K, Downing James R, Zhang Jinghui, Gilbertson Richard J
Abstract excerpt
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and matched normal blood. One-hundred and thirty-six genes harbouring somatic mutations in this discovery set were sequenced in an additional 56 medulloblastomas. Recurrent mutations were detected in 41 genes not yet...
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