Article
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.
Acta neuropathologica communications - 9 Feb 2023
Pun Matthew, Pratt Drew, Nano Patricia R, Joshi Piyush K, Jiang Li, Englinger Bernhard, Rao Arvind, Cieslik Marcin, Chinnaiyan Arul M, Aldape Kenneth, Pfister Stefan, Filbin Mariella G, Bhaduri Aparna, Venneti Sriram
Abstract excerpt
Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs). H3K27-altered DMGs are largely characterized by lysine-to-methionine mutations in histone 3 at position 27 (H3K27M). Most PFAs overexpress EZH inhibitory protein (EZHIP), which possesses a region of similarity to the mutant H3K27M. Both...
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