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Article

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

20 Jul 2020

Abstract excerpt

OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive multiomic analyses to identify an OTX2 regulatory network that controls Group 3 medulloblastoma cell fate. OTX2 silencing modulates the repressive chromatin landscape, decreases levels of PRC2 complex genes...

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PMID: 32686664
DOI: 10.1038/s41467-020-17357-4

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