Article
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.
Nature medicine - 1 Apr 2017
Piunti Andrea, Hashizume Rintaro, Morgan Marc A, Bartom Elizabeth T, Horbinski Craig M, Marshall Stacy A, Rendleman Emily J, Ma Quanhong, Takahashi Yoh-Hei, Woodfin Ashley R, Misharin Alexander V, Abshiru Nebiyu A, Lulla Rishi R, Saratsis Amanda M, Kelleher Neil L, James C David, Shilatifard Ali
Abstract excerpt
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor characterized by rapid and uniform patient demise. A heterozygous point mutation of histone H3 occurs in more than 80% of these tumors and results in a lysine-to-methionine substitution (H3K27M). Expression of this histone mutant is accompanied by a reduction in the levels of polycomb repressive complex 2 (PRC2)-mediated...
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