Article
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
Nature medicine - 1 Apr 2017
Mohammad Faizaan, Weissmann Simon, Leblanc Benjamin, Pandey Deo P, Højfeldt Jonas W, Comet Itys, Zheng Chunqin, Johansen Jens Vilstrup, Rapin Nicolas, Porse Bo T, Tvardovskiy Andrey, Jensen Ole N, Olaciregui Nagore G, Lavarino Cinzia, Suñol Mariona, de Torres Carmen, Mora Jaume, Carcaboso Angel M, Helin Kristian
Abstract excerpt
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor that is located in the pons and primarily affects children. Nearly 80% of DIPGs harbor mutations in histone H3 genes, wherein lysine 27 is substituted with methionine (H3K27M). H3K27M has been shown to inhibit polycomb repressive complex 2 (PRC2), a multiprotein complex responsible for the methylation of H3 at lysine 27 (H3K27me), by binding to...
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