Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma.

Acta neuropathologica communications - 17 Jul 2020

Georgescu M-M, Islam M Z, Li Y, Circu M L, Traylor J, Notarianni C M, Kline C N, Burns D K

Abstract excerpt

Diffuse midline gliomas (DMGs) are aggressive pediatric brain tumors with dismal prognosis due to therapy-resistant tumor growth and invasion. We performed the first integrated histologic/genomic/proteomic analysis of 21 foci from three pontine DMG cases with supratentorial dissemination. Histone H3.3-K27M was the driver mutation, usually at high variant allele fraction due to recurrent chromosome 1q copy number...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Stem Neoplasms
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Glioma

Share to High-Throughput Nucleotide Sequencing

Share to Histones

Share to Proteomics

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 32680567
DOI: 10.1186/s40478-020-00992-9
PMCID: PMC7367358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma.PMID 32680567Read ↗

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.Semantic proximity Read ↗

Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.Semantic proximity Read ↗

Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape.Semantic proximity Read ↗

Signal Transduction in Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma.Semantic proximity Read ↗

Diffuse intrinsic pontine glioma: current insights and future directionsSemantic proximity Read ↗

Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease.Semantic proximity Read ↗

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets.Semantic proximity Read ↗

H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions.Semantic proximity Read ↗

Distinct molecular profile of diffuse cerebellar gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.