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Article

EZHIP's role in diffuse midline glioma: echoes of oncohistones?

Trends in cancer - 1 Dec 2024

Cassim Afraah, Dun Matthew D, Gallego-Ortega David, Valdes-Mora Fatima

Abstract excerpt

The enhancer of zeste inhibitory protein (EZHIP) is typically expressed during germ cell development and has been classified as a cancer-testis antigen (CTA) in various cancers. In 2020, 4% of diffuse midline gliomas (DMGs) were shown to aberrantly express EZHIP, mirroring the DMG hallmark histone H3 K27M (H3K27M) oncohistone mutation. Similar to H3K27M, EZHIP is a negative regulator of polycomb repressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39343635
DOI: 10.1016/j.trecan.2024.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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