Article

Reproductive history differentially shapes the neural response of middle-aged females to estradiol therapy after a metabolic challenge

2026-01-16

Abstract excerpt

<h4>Background</h4> Advancing age, the APOE□4 allele, and female sex are the top nonmodifiable risk factors for Alzheimer’s disease (AD). Female-specific experiences, such as parity and hormone therapy (HT) affect aging biomarkers such as metabolism and immune signaling and may even affect AD risk. Estradiol (E2), a common component of many HTs, affects cognition and brain health in aging females although this ma...

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Literature Corpus work: 5d7382a1-7afd-5251-a063-4a1581ef8ac4
DOI: 10.64898/2026.01.15.699773

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