Article

Multi-modal single-cell and genetic integration defines cytotoxic T-cell regulatory states, HSPC suppression and inherited susceptibility in aplastic anaemia

2026-08-21

Abstract excerpt

Acquired aplastic anaemia is caused by immune-mediated loss of haematopoietic stem and progenitor cells (HSPCs), but the regulatory states that sustain cytotoxic immunity and their relationship to inherited susceptibility remain incompletely understood. We integrated two single-cell RNA-sequencing cohorts spanning healthy, non-severe and severe aplastic anaemia with single-cell chromatin accessibility profiling, g...

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Literature Corpus work: 77b78495-cd05-5284-bf97-f2d41b891fa9
DOI: 10.64898/2026.08.18.26360745

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