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Article

Molecular landscape of immune pressure and escape in aplastic anemia.

Leukemia - 1 Jan 2023

Pagliuca Simona, Gurnari Carmelo, Hercus Colin, Hergalant Sébastien, Nadarajah Niroshan, Wahida Adam, Terkawi Laila, Mori Minako, Zhou Weiyin, Visconte Valeria, Spellman Stephen, Gadalla Shahinaz M, Zhu Caiying, Zhu Ping, Haferlach Torsten, Maciejewski Jaroslaw P

Abstract excerpt

Idiopathic aplastic anemia (IAA) pathophysiology is dominated by autoreactivity of human leukocyte antigen (HLA)-restricted T-cells against antigens presented by hematopoietic stem and progenitor cells (HSPCs). Expansion of PIGA and HLA class I mutant HSPCs have been linked to immune evasion from T-cell mediated pressures. We hypothesized that in analogy with antitumor immunity, the pathophysiological cascade of...

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Share to Anemia, Aplastic
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobinuria, Paroxysmal

Share to Histocompatibility Antigens Class I

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 36253429
DOI: 10.1038/s41375-022-01723-w
PMCID: PMC10089624

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