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Article

Decoding immune-driven erythroid failure in pure red cell aplasia.

British journal of haematology - 1 May 2026

Spataro Federico, Desantis Vanessa, Solimando Antonio Giovanni

Abstract excerpt

Pure red cell aplasia (PRCA) is increasingly recognised as a T-cell-mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et al. integrate human leucocyte antigen (HLA) typing, T-cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles, signal transducer and activator of transcription 3 (STAT3)-mutated T-cell clones...

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Source

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Identifiers

PMID: 41940437
DOI: 10.1111/bjh.70473
PMCID: PMC13176509

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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