Article

Single-Cell Profiling Reveals Targetable Malignant T-Cell Subtypes and Immune Evasion Pathways in Sézary Syndrome

2025-05-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Sézary syndrome (SS) is a rare and aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) with limited therapeutic options and a median survival of fewer than five years. Despite advances in how single-cell RNA sequencing (scRNA-seq) has improved the understanding and treatment of other cancer types, such insights in SS remain limited. The drivers of disease progressi...

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Literature Corpus work: 076cbfa2-866d-5b5e-a93a-8830f4e1f169
DOI: 10.1101/2025.05.20.25327833

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