Article
Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.
American journal of human genetics - 6 Feb 2025
Jakubek Yasminka A, Ma Xiaolong, Stilp Adrienne M, Yu Fulong, Bacon Jason, Wong Justin W, Aguet Francois, Ardlie Kristin, Arnett Donna K, Barnes Kathleen, Bis Joshua C, Blackwell Tom, Becker Lewis C, Boerwinkle Eric, Bowler Russell P, Budoff Matthew J, Carson April P, Chen Jiawen, Cho Michael H, Coresh Josef, Cox Nancy J, de Vries Paul S, DeMeo Dawn L, Fardo David W, Fornage Myriam, Guo Xiuqing, Hall Michael E, Heard-Costa Nancy, Hidalgo Bertha, Irvin Marguerite Ryan, Johnson Andrew D, Jorgenson Eric, Kenny Eimear E, Kessler Michael D, Levy Daniel, Li Yun, Lima Joao A C, Liu Yongmei, Locke Adam E, Loos Ruth J F, Machiela Mitchell J, Mathias Rasika A, Mitchell Braxton D, Murabito Joanne M, Mychaleckyj Josyf C, North Kari E, Orchard Peter, Parker Stephen C J, Pershad Yash, Peyser Patricia A, Pratte Katherine A, Psaty Bruce M, Raffield Laura M, Redline Susan, Rich Stephen S, Rotter Jerome I, Shah Sanjiv J, Smith Jennifer A, Smith Aaron P, Smith Albert, Taub Margaret A, Tiwari Hemant K, Tracy Russell, Tuftin Bjoernar, Bick Alexander G, Sankaran Vijay G, Reiner Alexander P, Scheet Paul, Auer Paul L
Abstract excerpt
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole-genome sequencing (WGS) of a large set of...
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