Article

Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection

2023-01-31

Abstract excerpt

Mosaic loss of the X chromosome (mLOX) is the most commonly occurring clonal somatic alteration detected in the leukocytes of women, yet little is known about its genetic determinants or phenotypic consequences. To address this, we estimated mLOX in >900,000 women across eight biobanks, identifying 10% of women with detectable X loss in approximately 2% of their leukocytes. Out of 1,253 diseases examined, women wi...

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Literature Corpus work: 008ffea0-3da2-54aa-88b0-f4a39a9670c5
DOI: 10.1101/2023.01.28.23285140

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