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Article

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99.

Scientific reports - 26 Jul 2021

Mattisson Jonas, Danielsson Marcus, Hammond Maria, Davies Hanna, Gallant Caroline J, Nordlund Jessica, Raine Amanda, Edén Malin, Kilander Lena, Ingelsson Martin, Dumanski Jan P, Halvardson Jonatan, Forsberg Lars A

Abstract excerpt

Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated with increased risk for morbidity and mortality. The CD99 gene, positioned in the pseudoautosomal regions of chromosomes X and Y, encodes a cell surface protein essential for several key properties of leukocytes and immune system functions. Here we used CITE-seq for simultaneous quantification of CD99 derived mRNA and cell...

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Identifiers

PMID: 34312421
DOI: 10.1038/s41598-021-94588-5
PMCID: PMC8313698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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