Article

Bayesian Estimation of Mosaic Loss of Chromosome Y from Bulk RNA Sequencing Data

2026-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Mosaic loss of chromosome Y (LOY) is a common age-associated somatic alteration in men and is typically measured from DNA-based assays. Many cohorts, however, contain bulk RNA-seq data without matched DNA-based LOY measurements. We developed a Bayesian framework to estimate the fraction of cells with LOY from male bulk RNA-seq by modeling reduced Y-linked gene expression relative to expected exp...

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Literature Corpus work: 3d93430b-a905-5eab-8419-2333d59bc487
DOI: 10.64898/2026.05.20.726153

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