Article
Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
2019-03-13
Abstract excerpt
<h4>ABSTRACT</h4> Many current cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underlies treatment resistance. Here we introduce a new cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiPSCs) that capture authentic cancer pathobiology. Orthotopic engraftment of neural progenito...
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Identifiers and source
- Literature Corpus work
- 77a12ddc-4b51-56f9-bccc-4152b22823e0
- DOI
- 10.1101/576009