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Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression

21 Jan 2025

Abstract excerpt

Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study early tumor progression has hindered the development of effective therapies. Here, this study develops engineered GBM organoids (eGBOs) harboring GBM subtype-specific oncogenic mutations to investigate the underlying...

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PMID: 39836549
DOI: 10.1002/advs.202410110

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