Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.

doi:10.1038/s41467-020-14312-1

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Article

Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.

Nature communications - 28 Jan 2020

Koga Tomoyuki, Chaim Isaac A, Benitez Jorge A, Markmiller Sebastian, Parisian Alison D, Hevner Robert F, Turner Kristen M, Hessenauer Florian M, D'Antonio Matteo, Nguyen Nam-Phuong D, Saberi Shahram, Ma Jianhui, Miki Shunichiro, Boyer Antonia D, Ravits John, Frazer Kelly A, Bafna Vineet, Chen Clark C, Mischel Paul S, Yeo Gene W, Furnari Frank B

Abstract excerpt

Many cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underlies treatment resistance. Here we introduce a cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiPSCs) that captures authentic cancer pathobiology. Orthotopic engraftment of the neural progenitor cells derived from...

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Identifiers

PMID: 31992716
DOI: 10.1038/s41467-020-14312-1
PMCID: PMC6987220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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