Article

Modeling Glioma Intratumoral Heterogeneity with Primary Human Neural Stem and Progenitor Cells

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma multiforme (GBM) is a deadly form of glioma notable for its significant intratumoral heterogeneity, which is believed to drive therapy resistance. GBM has been observed to mimic a neural stem cell hierarchy reminiscent of normal brain development. However, it is still unclear how cell-of-origin shapes intratumoral heterogeneity. Here, we develop a model of glioma initiation using ne...

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Literature Corpus work: 57030c55-b5c7-5256-a7b1-9fb4d8f2b837
DOI: 10.1101/2024.10.20.619254

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