Article
Stem cell modeling of nervous system tumors.
Disease models & mechanisms - 1 Feb 2024
Furnari Frank B, Anastasaki Corina, Bian Shan, Fine Howard A, Koga Tomoyuki, Le Lu Q, Rodriguez Fausto J, Gutmann David H
Abstract excerpt
Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective therapies for these cancers. Although human nervous system tumor cells and genetically engineered mouse models have served as excellent platforms for drug discovery and preclinical testing, they have limitations with...
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