Article

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

2020-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Patient-derived cancer models are essential tools for studying tumor biology and preclinical interventions. Here, we show that glioma patient-derived orthotopic xenografts (PDOXs) enable long-term propagation of patient tumors and represent clinically relevant patient avatars. We created a large collection of PDOXs from primary and recurrent gliomas with and without mutations in IDH1 , which re...

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Literature Corpus work: 91200c81-70af-5ef7-a1b6-f5071b23d2b2
DOI: 10.1101/2020.04.24.057802

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