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Article

Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells.

Stem cell reports - 9 Sept 2025

Liu Daniel Dan, Gao Daniel, Womack-Gambrel Nicole L, Eastman Anna E, Ohene-Gambill Benjamin F, Weissman Irving L

Abstract excerpt

Gliomas are notorious for their intratumoral heterogeneity, which drives therapy resistance. Glioma tumor cells mimic a neural stem cell (NSC) hierarchy reminiscent of normal brain development. How intratumoral heterogeneity is shaped by cell-of-origin and various driver mutations is not fully understood. We develop a model of glioma initiation using neural stem and progenitor cells (NSPCs) purified from...

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Identifiers

PMID: 40749669
DOI: 10.1016/j.stemcr.2025.102597
PMCID: PMC12447335

Genes

CDK4
EGFR
NF1
PDGFRA
TP53

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