Article

Modeling glioblastoma tumor progression via CRISPR-engineered brain organoids

2024-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study early tumor progression has hindered the development of effective therapies. Here, we develop engineered GBM organoids (eGBOs) harboring GBM subtype-specific oncogenic mutations to investigate the underlying trans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b02be74-48a5-5ad2-9cf5-fc2b7329c8b6
DOI: 10.1101/2024.08.02.606387

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling glioblastoma tumor progression via CRISPR-engineered brain organoidsDOI 10.1101/2024.08.02.606387Read

Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma ProgressionSemantic proximity Read

Modeling Patient-Derived Glioblastoma with Cerebral OrganoidsSemantic proximity Read

TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitroSemantic proximity Read

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant gliomaSemantic proximity Read

Single-cell landscapes of primary glioblastomas and matched organoids and cell lines reveal variable retention of inter- and intra-tumor heterogeneitySemantic proximity Read

Modeling nervous system tumors with human stem cells and organoidsSemantic proximity Read

Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneitySemantic proximity Read

Genetically engineered cerebral organoids model brain tumor formation.Semantic proximity Read

Advancing Glioblastoma Research with Innovative Brain Organoid-Based ModelsSemantic proximity Read

Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivitySemantic proximity Read

Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor developmentSemantic proximity Read

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read