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Article

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

1 Mar 2019

Abstract excerpt

The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a "normal" human microenvironment and the inability of many tumor cell lines to accurately reproduce GBM biology. To address these limitations, we have established a model system whereby we can retro-engineer patient-specific GBMs using...

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PMID: 30893594
DOI: 10.1016/j.celrep.2019.02.063

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