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Chromosome 1 trisomy overcomes the block of sphingolipid biosynthesis caused by aureobasidin A and confers pleiotropic effects on susceptibility to antifungals in <i>Candida albicans</i>

2020-04-09

Abstract excerpt

Sphingolipids are important membrane lipid components of eukaryotic cells. In Candida albicans , chromosome 1 trisomy not only overcame the block of sphingolipid biosynthesis caused by aureobasidin A, but also altered tolerance to three of the four major classes of antifungal drugs. Two haploinsufficient genes on chromosome 1, PDR16 and IPT1 , were associated with tolerance to aureobasidin A. This study illustr...

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Literature Corpus work
779e5e55-b6dd-5d10-b5f3-9df93e28dfa7
DOI
10.1101/2020.04.07.031112
Open publication

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