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Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis

7 Oct 2021

Abstract excerpt

Candida parapsilosis is an emerging human fungal pathogen, especially prevalent in neonates. Aneuploidy, having uneven numbers of chromosomes, is a well-known mechanism for adapting to stress in Candida albicans, the most common human fungal pathogen. In this study, we exposed C. parapsilosis to two very different drugs and selected for rare cells that grew in one of the drugs. We found that the majority of...

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PMID: 34612700
DOI: 10.1128/spectrum.00508-21

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