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Article

Aneuploidy and Isochromosome Formation in Drug-Resistant <i>Candida albicans</i>

20 Jul 2006

Abstract excerpt

Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans. We found that aneuploidy in general and a specific segmental aneuploidy, consisting of an isochromosome composed of the two left arms of chromosome 5, were associated with azole resistance. The isochromosome forms around a single centromere flanked by an inverted repeat and was found as an...

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PMID: 16857942
DOI: 10.1126/science.1128242

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