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Resistance to miltefosine results from amplification of the <i>RTA3</i> floppase or inactivation of flippases in <i>Candida parapsilosis</i>

2021-12-17

Abstract excerpt

Flippases and floppases are two classes of proteins that have opposing functions in the maintenance of lipid asymmetry of the plasma membrane. Flippases translocate lipids from the exoplasmic leaflet to the cytosolic leaflet, and floppases act in the opposite direction. Phosphatidylcholine (PC) is a major component of the eukaryotic plasma membrane and is asymmetrically distributed, being more abundant in the exop...

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Literature Corpus work
a252f5b1-41a8-5407-85f8-c163570691a0
DOI
10.1101/2021.12.16.473093
Open publication

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