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Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis

11 Apr 2023

Abstract excerpt

Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections. In clinical isolates, tolerance to echinocandins in Candida species is mostly due to point mutations of FKS genes, which encode the target protein of echinocandins. However, here, we found chromosome 5 trisomy was the major mechanism of adaptation to the...

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PMID: 37113223
DOI: 10.3389/fmicb.2023.1137083

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