Article

Brain cross-omics integration in Alzheimer’s disease

2022-12-13

Abstract excerpt

Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning approaches to integrate high-throughput bulk and single-nucleus transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical and neuropathological data from multiple AD cohorts. We discovered four unique multimodal molecular profiles, one showing signs of poor cognitiv...

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Literature Corpus work: 192bbb5b-e184-552f-8666-190af2f8ff1c
DOI: 10.1101/2022.12.10.22283295

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