Article

Rapamycin Reduces Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification

2024-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Peripheral artery disease (PAD) is the narrowing of the arteries that carry blood to the lower extremities. PAD has been traditionally associated with atherosclerosis. However, recent studies have found that thrombotic events triggered by medial arterial calcification (MAC) is the primary cause of chronic limb ischemia below the knee. MAC is localized around the elastic fibers surrounding smooth...

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Literature Corpus work: 773f22ab-21bc-5a4e-b550-ea7e172f2ab2
DOI: 10.1101/2024.08.01.606196

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