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Article

Prevention of arterial calcification corrects the low bone mass phenotype in MGP-deficient mice.

Bone - 1 Dec 2013

Marulanda Juliana, Gao Chan, Roman Hassem, Henderson Janet E, Murshed Monzur

Abstract excerpt

Matrix gla protein (MGP), a potent inhibitor of extracellular matrix (ECM) mineralization, is primarily produced by vascular smooth muscle cells (VSMCs) and chondrocytes. Consistent with its expression profile, MGP deficiency in mice (Mgp-/- mice) results in extensive mineralization of all arteries and cartilaginous ECMs. Interestingly, we observed a progressive loss of body weight in Mgp-/- mice, which becomes...

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Source

Identifiers

PMID: 23994172
DOI: 10.1016/j.bone.2013.08.021

Genes

MGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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