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Article

Proteomics reveals Rictor as a noncanonical TGF-β signaling target during aneurysm progression in Marfan mice.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2018

Parker Sarah J, Stotland Aleksandr, MacFarlane Elena, Wilson Nicole, Orosco Amanda, Venkatraman Vidya, Madrid Kyle, Gottlieb Roberta, Dietz Harry C, Van Eyk Jennifer E

Abstract excerpt

The objective of the present study was to 1) analyze the ascending aortic proteome within a mouse model of Marfan syndrome (MFS; Fbn1C1041G/+) at early and late stages of aneurysm and 2) subsequently test a novel hypothesis formulated on the basis of this unbiased proteomic screen that links changes in integrin composition to transforming growth factor (TGF)-β-dependent activation of the rapamycin-independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30004239
DOI: 10.1152/ajpheart.00089.2018
PMCID: PMC6335018

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