1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification.

doi:10.1161/CIRCRESAHA.125.326772

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1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification.

Circulation research - 30 Jan 2026

Hense Nicolas, Gorgels Andrea, Mir Bilal, van der Vorst Emiel P C, Falgayrac Guillaume, Terliesner Mara, Goncalves Isabel, Matic Ljubica, Edsfeldt Andreas, Sun Jiangming, Hedin Ulf, Hayat Sikander, Thiel Jessica, Ramirez-Torres Maria Alejandra, Barsoum Mirna, Rauch Alexander, Rauner Martina, Gombert Alexander, Preisinger Christian, Noels Heidi, Marx Nikolaus, Goettsch Claudia

Abstract excerpt

BACKGROUND: Cardiovascular calcification is a significant predictor and contributor to cardiovascular diseases. Vascular smooth muscle cell (SMC)-derived extracellular vesicles (EVs) play a crucial role in microcalcification formation. EVs can originate from the endosomal system, and PIKFYVE (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays a key role in endomembrane maturation. We hypothesize...

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PMID: 41533526
DOI: 10.1161/CIRCRESAHA.125.326772

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PIKFYVE

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