Article

The role of Platelet-derived growth factor (PDGF) in uremic vascular calcification

2025-07-15

Abstract excerpt

Vascular calcification is common in chronic kidney disease (CKD), contributing to increased cardiovascular morbidity and mortality. One of the proposed mechanisms of driving vascular calcification is a phenotypic switch of vascular smooth muscle cells (VSMCs). The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs), particularly PDGFR-β, were shown to modulate the VSMC phenotype. However, their ro...

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Literature Corpus work: 9bee1ead-74e2-5618-bb4c-209a7422ab52
DOI: 10.1101/2025.07.09.664016

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