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Article

Inhibition of vascular intimal hyperplasia by the myokine Musclin: the role of NPR3/raptor/mTORC1-mediated glycolysis and phenotypic switching of VSMCs.

Acta biochimica et biophysica Sinica - 10 Oct 2025

Wei Shanwu, Xiong Mi, Li De, Deng Xiangxiang, Guo Wei, Sun Xiongshan

Abstract excerpt

Skeletal muscle-derived Musclin exerts multiple effects on the cardiovascular system. However, the role of Musclin in vascular intimal hyperplasia (IH) remains unclear. This study aims to investigate the role and underlying mechanism of Musclin in IH. We overexpress Musclin in skeletal muscle via adeno-associated virus serotype 6 (AAV6)-mediated gene transfer (AAV- Musclin) in an injury-induced mouse vascular IH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mechanistic Target of Rapamycin Complex 1

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Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 41074587
DOI: 10.3724/abbs.2025174
PMCID: PMC13448985

Genes

NPR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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