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Article

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2015

Sheen Campbell R, Kuss Pia, Narisawa Sonoko, Yadav Manisha C, Nigro Jessica, Wang Wei, Chhea T Nicole, Sergienko Eduard A, Kapoor Kapil, Jackson Michael R, Hoylaerts Marc F, Pinkerton Anthony B, O'Neill W Charles, Millán José Luis

Abstract excerpt

Medial vascular calcification (MVC) is a pathological phenomenon that causes vascular stiffening and can lead to heart failure; it is common to a variety of conditions, including aging, chronic kidney disease, diabetes, obesity, and a variety of rare genetic diseases. These conditions share the common feature of tissue-nonspecific alkaline phosphatase (TNAP) upregulation in the vasculature. To evaluate the role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25428889
DOI: 10.1002/jbmr.2420
PMCID: PMC4406354

Genes

ALPL

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