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Article

Inhibition of FOXO1/3 promotes vascular calcification.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2015

Deng Liang, Huang Lu, Sun Yong, Heath Jack M, Wu Hui, Chen Yabing

Abstract excerpt

OBJECTIVE: Vascular calcification is a characteristic feature of atherosclerosis, diabetes mellitus, and end-stage renal disease. We have demonstrated that activation of protein kinase B (AKT) upregulates runt-related transcription factor 2 (Runx2), a key osteogenic transcription factor that is crucial for calcification of vascular smooth muscle cells (VSMC). Using mice with SMC-specific deletion of phosphatase...

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Source

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Identifiers

PMID: 25378413
DOI: 10.1161/ATVBAHA.114.304786
PMCID: PMC4270841

Genes

PTEN
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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