Article

Tau-induced mitochondrial reverse electron transport drives neurodegeneration

2026-04-07

Abstract excerpt

Hyperphosphorylation and aggregation of the microtubule-associated protein tau are recognized as pathological hallmarks of tauopathies; however, the biological activity of tau that drives its pathophysiological effects remains poorly understood 1–6 . Mitochondrial dysfunction is a common feature of tauopathies 7,8 . Despite this, the mechanistic link between tau abnormalities and mitochondrial dysfunction, as we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7729cb6b-ddf3-50e0-aa67-d9d53dca427f
DOI: 10.64898/2026.04.04.716514

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tau-induced mitochondrial reverse electron transport drives neurodegenerationDOI 10.64898/2026.04.04.716514Read

<p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span style="mso-bidi-font-size: 18.0pt; mso-ligatures: standardcontextual;">5-ALA/SFC Mitigates Tau Toxicity via Lowering Oxidative Stress in a <em>Drosophila</em> Model of Tau ToxicitySemantic proximity Read

A new link to mitochondrial impairment in tauopathies.Semantic proximity Read

Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics.Semantic proximity Read

Tau promotes neurodegeneration via DRP1 mislocalization in vivo.Semantic proximity Read

Mitochondrial perturbation drives tau oligomers pathology in Alzheimer’s diseaseSemantic proximity Read

Insights from Drosophila on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and toolsSemantic proximity Read

Signs of early cellular dysfunction in multiple system atrophySemantic proximity Read

Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's diseaseSemantic proximity Read

Mitochondrial and redox modifications in early stages of Huntington's diseaseSemantic proximity Read

Embryonic Stem Cell–Based Modeling of Tau Pathology in Human NeuronsSemantic proximity Read

Mitochondrial and redox modifications in early stages of Huntington’s diseaseSemantic proximity Read

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In VivoSemantic proximity Read