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Embryonic Stem Cell–Based Modeling of Tau Pathology in Human Neurons

12 Mar 2013

Abstract excerpt

Alterations in the microtubule (MT)-associated protein, tau, have emerged as a pivotal phenomenon in several neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease. Although compelling lines of evidence from various experimental models suggest that hyperphosphorylation and conformational changes of tau can cause its aggregation into filaments, the actual tau species and effective...

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PMID: 23499461
DOI: 10.1016/j.ajpath.2013.01.043

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