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Article

Signs of early cellular dysfunction in multiple system atrophy

11 Sept 2020

Abstract excerpt

AIMS: Multiple system atrophy (MSA) is a fatal neurodegenerative disease that belongs to the family of α-synucleinopathies. At post mortem examination, intracellular inclusions of misfolded α-synuclein are found in neurons and oligodendrocytes and are considered to play a significant role in the pathogenesis. However, the early steps of the disease process are unknown and difficult to study in tissue derived from...

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PMID: 32892415
DOI: 10.1111/nan.12661

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