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Insights from Drosophila on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and tools

17 Apr 2023

Abstract excerpt

Alzheimer’s disease (AD) is the most prevalent neurodegenerative dementia in older adults worldwide. Sadly, there are no disease-modifying therapies available for treatment due to the multifactorial complexity of the disease. AD is pathologically characterized by extracellular deposition of amyloid beta (Aβ) and intracellular neurofibrillary tangles composed of hyperphosphorylated tau. Increasing evidence suggest...

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PMID: 37139514
DOI: 10.3389/fnins.2023.1184080

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