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Article

A new link to mitochondrial impairment in tauopathies.

Molecular neurobiology - 1 Aug 2012

Schulz Kathrin L, Eckert Anne, Rhein Virginie, Mai Sören, Haase Winfried, Reichert Andreas S, Jendrach Marina, Müller Walter E, Leuner Kristina

Abstract excerpt

Tauopathies like the "frontotemporal dementia with Parkinsonism linked to chromosome 17" (FTDP-17) are characterized by an aberrant accumulation of intracellular neurofibrillary tangles composed of hyperphosphorylated tau. For FTDP-17, a pathogenic tau mutation P301L was identified. Impaired mitochondrial function including disturbed dynamics such as fission and fusion are most likely major pathomechanisms of...

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Identifiers

PMID: 22847631
DOI: 10.1007/s12035-012-8308-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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