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Mitochondrial and redox modifications in early stages of Huntington's disease

10 Aug 2022

Abstract excerpt

Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and can be detected in vivo is still unclear. In the present study, we analysed changes in mitochondrial function and production of reactive oxygen species (ROS) at early...

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PMID: 35988447
DOI: 10.1016/j.redox.2022.102424

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