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Article

Tau promotes neurodegeneration via DRP1 mislocalization in vivo.

Neuron - 23 Aug 2012

DuBoff Brian, Götz Jürgen, Feany Mel B

Abstract excerpt

Mitochondrial abnormalities have been documented in Alzheimer's disease and related neurodegenerative disorders, but the causal relationship between mitochondrial changes and neurodegeneration, and the specific mechanisms promoting mitochondrial dysfunction, are unclear. Here, we find that expression of human tau results in elongation of mitochondria in both Drosophila and mouse neurons. Elongation is accompanied...

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Identifiers

PMID: 22920254
DOI: 10.1016/j.neuron.2012.06.026
PMCID: PMC3428596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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