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Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

8 Mar 2010

Abstract excerpt

The histopathological characteristics of Alzheimer's disease (AD) are amyloid-beta (Abeta) containing plaques and neurofibrillary tangles (NFTs) as well as neuronal and synaptic loss. Until today, the underlying mechanisms of the interplay of plaques and tangles remained unresolved. There is increasing evidence that mitochondrial dysfunction might be a possible link, as revealed by studies in several APP and tau...

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PMID: 20217279
DOI: 10.1007/s12035-010-8109-5

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