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Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease

1 Jul 2025

Abstract excerpt

INTRODUCTION: Impaired mitochondrial function is seen in Alzheimer's disease (AD), but its role is unclear. Mitochondrial DNA (mtDNA) supports bioenergetic metabolism, but it is uncertain how it might influence AD neuropathology. METHODS: We used cytoplasmic hybrid (cybrid) cell lines made from SH-SY5Y cells expressing mtDNA from cognitively healthy (CH), mild cognitive impairment (MCI), or AD individuals to...

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PMID: 40596736
DOI: 10.1002/alz.70390

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