Article

Mitochondrial perturbation drives tau oligomers pathology in Alzheimer’s disease

2020-07-24

Abstract excerpt

<title>Abstract</title> <p>Tau oligomers, prior to neurofibrillary tangle formation, are toxic species responsible for tau pathology, mitochondrial and synaptic damage, and memory impairment. The underlying mechanisms of abnormal tau accumulation and strategies to eliminate them remain largely unknown. The present study addresses whether mitochondrial reactive oxygen species (ROS) are major contributing factors f...

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Literature Corpus work: 98ad33de-c25f-56c6-bb1e-652556b294f6
DOI: 10.21203/rs.3.rs-40746/v1

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