Article

Natural isolate and recombinant SARS-CoV-2 rapidly evolve in vitro to higher infectivity through more efficient binding to heparan sulfate and reduced S1/S2 cleavage

2021-06-29

Abstract excerpt

<h4>ABSTRACT</h4> One of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virulence factors is the ability to interact with high affinity to the ACE2 receptor, which mediates viral entry into cells. The results of our study demonstrate that within a few passages in cell culture, both the natural isolate of SARS-CoV-2 and the recombinant, cDNA-derived variant acquire an additional ability to bind t...

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Literature Corpus work: 77283899-e029-5c1d-9f32-0912db84fd3f
DOI: 10.1101/2021.06.28.450274

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